Treatment with galcanezumab, also known as Emgality

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Emgality is used as a preventive treatment for migraines.

The preparation

Emgality has been developed specifically to prevent migraines and is approved for adults who have at least 4 seizures a month.

Mechanism of action

It is known that CGRP (calcitonin gene-related peptide), which is formed in our nervous system, plays an active role in a migraine attack.

Emgality works by binding specifically to and blocking the activity of the CGRP molecule in the brain. This can decrease the number and strength of your migraine attacks.

Emgality has a half-life of about 27 days.

Side effects

Reaction around the injection site, skin itching, rash and constipation. Very rarely anaphylactic reaction.

Precautionary measures

You should not use Emgality if you have certain forms of cardiovascular disease.

Emgality must not be used by pregnant women and breast-feeding mothers.

You must stop taking Emgality at least 5 months before you try to get pregnant.

Before starting treatment

Checked blood pressure

What dose to take?

The first time you take Emgality, you should have a shock dose, i.e. 2 pens of 120 mg each.

Going forward, inject 1 dose of 120 mg once every month (one pen).

How is Emgality taken?

We recommend that you take Emgality out of the refrigerator about ½ hour before use.

Do not shake the EmgalityPen.

Emgality can be injected into either the thigh or abdomen. If you have one to help you, it can also be injected into the upper arm.

Check that the liquid in the pen is clear and without precipitate.

  1. Turn the white triangular cap of the pen in the direction of the arrow
  2. Stretch or squeeze the skin where you want to inject.
  3. The pen is placed at a 90 degree angle to the skin
  4. Slide the white marker from the locked to the open position, marked with a padlock.
  5. Press the green button at the bottom. It is important that you maintain pressure until the piston in the window has collapsed and has given a “click”.
  6. The used pen is discarded in the bag provided and can be returned to the pharmacy for recycling.

Storage

When dispensing Emgality, be sure to put it in the refrigerator within 4 hours. Store Emgality in a refrigerator at 2-8°C protected from light. Does not tolerate frost.

Can be stored for up to 7 days at max 30°C. Unused pens must then be discarded.

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